Minister for Health James Reilly has announced that the Government has approved the cystic fibrosis drug Kalydeco for use in Ireland from 1 March.
The National Centre for Pharmacoeconomics recently recommended against its sanction for use at a cost of more than €234,000 per patient per year.
Further discussions with the manufactures have resulted in significant savings in the cost.
The drug can lead to significant improvements for patients with a particular mutation of cystic fibrosis.
It is understood that around 120 people will benefit from the announcement.
The drug will cost in excess of €20m per annum.
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