Three men were killed when a double-decker coach collided with a stationary car on the M1 in Bedfordshire, police have said.
The victims, all travelling in the hatch-back car, which had stopped on the hard shoulder, were pronounced dead at the scene near Flitwick.
No one on the coach was hurt in the crash at about 6.45am, but a fourth occupant of the car was taken to Oxford's John Radcliffe Hospital with serious injuries.
Meanwhile, at least one person is understood to have died in a 30-car motorway pile-up in fog this morning in the UK.
Paramedics are still assessing more than 30 patients for possible injuries.
The crash happened on the M40, near a busy designer outlet shopping centre in Bicester, Oxfordshire, just before 7.50am.
The AA said the area was busy with traffic as families hit the roads for a getaway as schools are on their half-term break.
Pictures posted on Twitter show cars at a standstill in thick fog on the motorway, while drivers and passengers stand around.
Forecasters said Oxfordshire was hit by fog this morning, which would have hampered visibility.
The motorway has been closed northbound between junctions 9 and 10, while a couple of southbound lanes are shut along the same stretch.
An ambulance spokeswoman said it is too early to know the nature and severity of the injuries suffered by drivers.
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