The opposition Syrian National Coalition said it is willing to negotiate a peace deal to end the country's civil war.
But in a communiqué issued for an opposition meeting, it said President Bashar al-Assad cannot be a party to any settlement.
The communiqué, seen by Reuters, omitted a direct demand for Mr Assad's removal, in a softening of tone from past positions that insisted the president must go before there could be any talks.
It will be debated at a meeting of the opposition alliance's leadership starting in Cairo later today.
The SNC said Mr Assad and his cohorts must be held accountable for bloodshed and that any peace deal must be under the auspices of the US and Russia.
"Bashar al-Assad and the military and security apparatus commands are responsible for the decisions that have led the country to what it is now are outside the political process and are not part of any political solution in Syria," it said.
"They have to be held accountable for the crimes they have committed."
The initiative comes from coalition president Moaz Alkhatib, a cleric from Damascus, who played a role in the peaceful protest movement against Mr Assad at the beginning of the uprising almost two years ago.
Explosion reported in central Damascus
Meanwhile, a large explosion shook the central Damascus district of Mazraa and there are reports that 31 people have been killed.
Syrian state media blamed what it said was a suicide bombing on "terrorists" battling President Assad.
Syrian television broadcast footage of at least four bodies on a main street and firefighters dousing the charred remains of dozens of burning vehicles.
Black smoke billowed into the sky.
It said casualties included children at a nearby school in the residential district of the capital. Debris was spread over a wide area.
The Syrian Observatory for Human Rights, a Britain-based group that monitors violence in the country, said a car bomb had detonated near a building of the ruling Baath Party.
Russia and Arab League offer to engage with Syria
Russia and the Arab League have proposed brokering direct talks in an attempt to end the civil war in Syria.
Russian Foreign Minister Sergei Lavrov said the violence was "a road to mutual destruction".
Russia still keeps close ties with the regime of President Assad, and has so far refused to halt military cooperation with Syria.
The proposal received a cool reception from the opposition.
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